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Researchers have found that editing genes with Crispr is more difficult than expected because the p53 gene detects breaks in DNA and kills edited cells as if they were cancer cells.

https://www.nytimes.com/2018/06/12/science/crispr-cancer-gene-editing.html?emc=edit_th_180613&nl=todaysheadlines&nlid=730171970613

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